Bayer Leverkusen has sold goalkeeper Bernd Leno to Arsenal for around €19 million, completing Unai Emery’s second major signing as manager.The 26-year-old German international Leno has arrived on a contract that should keep him at the Emirates until 2023, making him the long-term replacement for current number one Petr Cech, reports Four-Four-Two. Emery was delighted after unveiling his latest acquisition, saying: “We are very pleased that Bernd Leno will be joining us,”“Bernd is a goalkeeper of high quality and experience. We are all excited that Bernd has chosen Arsenal and look forward to start working with him in pre-season.” Merson believes Arsenal should sign Sancho Manuel R. Medina – September 14, 2019 Borussia Dortmund winger Jadon Sancho might be the perfect player to play for the Gunners, according to former England international Paul Merson.Welcome to Arsenal, @Bernd_Leno – we’re delighted to have you here ?#HeyLeno pic.twitter.com/m4yT22I58V— Arsenal FC (@Arsenal) June 19, 2018Leno was a major part of the Leverkusen squad that achieved a 5th place finish in the Bundesliga last year and he has won 6 caps for his country to date – though unfortunately, he did not make Joachim Lowes final squad for the World Cup.After the purchase of Stephan Lichtsteiner last month, Emery has managed to further enhance his options defensively with the signing of Leno, as his new look Arsenal side begins to take shape.
Arsenal midfielder Lucas Torreira has revealed he received a surprise phone call from Unai Emery during the World Cup in Russia.Emery, who was appointed manager of the Gunners at the end of last season phoned Torreira to personally persuade him to move to Arsenal.The Uruguay international confessed they were a host of teams interested in his services during the summer transfer window but he never thought he would move to England.However, one phone call from the former Paris Saint-Germain boss changed everything.Following his country’s exit from the World Cup the North London club didn’t waste any time signing the midfielder, securing him on a £22million deal.Premier League Betting: Match-day 5 Stuart Heath – September 14, 2019 Going into the Premier League’s match-day five with a gap already beginning to form at the top of the league. We will take a…“At the end of my last season at Sampdoria there were lots of teams being talked about,” Torreira told Arsenal media as quoted in the Mirror.“I never imagined coming here to England because it was mainly Italian clubs being mentioned.”“Before I left for the World cup I got a call from the coach which was a massive surprise for me. I knew that I had earned it because of all my hard work and everything that I had done. That phone call made me a happy man.”“It allowed me to relax too because it allowed me to focus all my attention on the national team and the World Cup. I’m so proud to be part of such an important team.”
Enlarge ImageShots of cars in sand dunes never get old. Land Rover We’re slowly approaching the point where Land Rover will finally pull back the veil on its hotly anticipated 2020 Defender SUV. However, today isn’t that day, which means we’ll have to live with more cool pictures of a camouflaged Defender for now. Shucks.Land Rover on Friday released a new smattering of pictures showing the 2020 Defender tackling the sand dunes in Dubai. Part of the Defender’s testing program ahead of its official unveiling, Land Rover teamed up with the International Federation of Red Cross and Red Crescent Societies to give this little ute the ol’ what-for in an area where its buyers are likely to travel.Out in Dubai, the Defender didn’t just whip around the dunes. It also tackled hairpin curves on the Jebel Jais highway. Temperatures shot past the triple-digit mark, which makes it a great place to suss out the Defender’s high-temp behavior, as well. It also tackled altitudes well above the one-mile mark, ensuring its engine doesn’t choke itself out when the air gets thin. Share your voice Land Rover Tags 2018 Range Rover Velar: Effortless SUV elegance on- and off-road Land Rover Post a comment 33 Photos SUVs Luxury cars Future Cars 2020 Land Rover Range Rover Evoque review: Style, now with more substance Land Rover first announced the return of the Defender in late 2018, and it revealed that the model would finally return to the US, as well, following a 23-year absence. Its boxy good looks have remained hidden by camouflage, but Land Rover hasn’t been shy about throwing out a whole lot of teasers ahead of its anticipated debut, which could come as early as the Frankfurt Motor Show in September. Even rumors have been few and far between. The most notable one we’ve heard about, though, is that the Defender will be available in three sizes — 90, 110 and 130, with the smallest being a three-door model. We’ve also seen what appears to be the Defender’s interior thanks to some clever spy shots. If you can’t afford one, don’t worry, because Lego has a Technic Defender coming out, which should be significantly easier on the wallet. 2020 Land Rover Defender hits the dunes of Dubai More From Roadshow 0 2019 Land Rover Range Rover P400e review: A hard hybrid to recommend
“UVA played mistake-free doubles to open up the match,” said UofL head coach Rex Ecarma. “They won four deuce points early and we were fighting from behind. After they won No. 1 singles, the rest of the matches could have gone either way. David won and Sergio was winning. Fabien was up in the second set early. It’s obvious we have a special group of freshmen. UVA added two players in their top four. They are very improved team from last year.” #17 Virginia 4, Louisville 11/20/2019 at Charlottesville, Va.(Boar’s Head Sports Club)Singles1. Carl Soderlund (VA) def. #104 Brandon Lancaster (LOU) 6-1, 6-02. Brandon Nakashima (VA) vs. Christopher Morin-Kougoucheff (LOU) 6-3, 6-5, unfinished3. #38 Gianni Ross (VA) def. Fabien Salle (LOU) 6-2, 7-54. Henrik Wiersholm (VA) def. Federico Gomez (LOU) 6-3, 6-45. Aswin Lizen (VA) vs. Sergio Hernandez Ramirez (LOU) 3-6, 5-5, unfinished6. David Mizrahi (LOU) def. Matthew Lord (VA) 1-6, 6-2, 6-3Doubles1. Carl Soderlund/Matthew Lord (VA) vs. Christopher Morin-Kougoucheff/Fabien Salle (LOU) 5-3, unfinished2. Aswin Lizen/Gianni Ross (VA) def. Brandon Lancaster/Alex Wesbrooks (LOU) 6-33. Brandon Nakashima/Henrik Wiersholm (VA) def. Federico Gomez/Sergio Hernandez Ramirez (LOU) 6-1 The match was decided on court three where No. 38 Gianni Ross defeated freshman Fabien Salle 6-2, 7-5 for the 4-1 final. Virginia (2-0, 1-0 ACC) started the match by taking the doubles points with wins on courts 2 and 3. The Cavalier duo of Brandon Nakashima and Henrik Wiersholm defeated Lousville’s Federico Gomez and Sergio Hernandez Ramirez 6-1 at No. 3 and clinched the point at the two-spot where Aswin Lizen and Gianni Ross topped Brandon Lancaster and Alex Wesbrooks 6-3. Matchup History Preview The University of Louisville men’s tennis team fell 4-1 to No. 17 Virginia in its ACC opener Sunday in Charlottesville, Va. In singles action, Carl Soderlund defeated No. 104 Lancaster at the No. 1 seed to give Virginia a 2-0 lead. Wiersholm defeated Gomez 6-3, 6-4 at the four-spot to make the score 3-0. David Mizrahi put the Cardinals on the scoreboard with a 1-6, 6-2, 6-3 win over Matthew Lord at No. 6. With the victory, the freshman improves his dual match record to a team-best 4-0. Up next, the Cardinals (3-1, 0-1 ACC) will travel to Gainesville, Fla., to face Florida Atlantic in the first round of the ITA Kick-Off Weekend. Next Match: vs. Florida Atlantic 1/26/2019 | 11:00 a.m. Match Notes:Louisville 3-1, 0-1 ACCVirginia 2-0, 1-0 ACC; National ranking #17Order of finish: Doubles (3,2); Singles (1,4,6,3)T-2:00 A-257 Print Friendly Version Full Schedule Roster
Play Movie of nanoparticles moving through mucus. Credit: Schneider et al. Sci. Adv. 2017;3:e1601556 The nanoparticles, the team notes, were created using biodegradable materials that prior research found safe for internal use. Testing in mice, they report, showed the particle carriers stayed in the lungs for several hours—they also proved to be more effective than conventional therapies at reducing asthma symptoms such as irritation. The researchers suggest that MPPs could offer a better treatment plan for lung patients by providing a therapy that maintains drug levels in the lungs for longer periods of time, reducing the need for repeated dosing, which itself can cause lung irritation. PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen More information: Craig S. Schneider et al. Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation, Science Advances (2017). DOI: 10.1126/sciadv.1601556AbstractMucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that avoid mucoadhesion and have diameters smaller than mucus mesh spacings rapidly penetrate mucus layers [mucus-penetrating particles (MPP)], which we hypothesized would provide prolonged lung retention compared to MAP. We compared in vivo behaviors of variously sized, polystyrene-based MAP and MPP in the lungs following inhalation. MAP, regardless of particle size, were aggregated and poorly distributed throughout the airways, leading to rapid clearance from the lungs. Conversely, MPP as large as 300 nm exhibited uniform distribution and markedly enhanced retention compared to size-matched MAP. On the basis of these findings, we formulated biodegradable MPP (b-MPP) with an average diameter of <300 nm and examined their behavior following inhalation relative to similarly sized biodegradable MAP (b-MAP). Although b-MPP diffused rapidly through human airway mucus ex vivo, b-MAP did not. Rapid b-MPP movements in mucus ex vivo correlated to a more uniform distribution within the airways and enhanced lung retention time as compared to b-MAP. Furthermore, inhalation of b-MPP loaded with dexamethasone sodium phosphate (DP) significantly reduced inflammation in a mouse model of acute lung inflammation compared to both carrier-free DP and DP-loaded MAP. These studies provide a careful head-to-head comparison of MAP versus MPP following inhalation and challenge a long-standing dogma that favored the use of MAP for pulmonary drug delivery. Play Movie of nanoparticles moving through mucus. Credit: Schneider et al. Sci. Adv. 2017;3:e1601556 Citation: Nanoparticles pass through mucus membranes in lungs to deliver pulmonary drugs (2017, April 6) retrieved 18 August 2019 from https://phys.org/news/2017-04-nanoparticles-mucus-membranes-lungs-pulmonary.html Journal information: Science Advances Lung problems impact the lives of millions of people. Such conditions include asthma, in which bronchi spasm, making it difficult to breathe; cystic fibrosis, in which over-production of mucus leads to blocking of bronchi; and COPD, in which obstructions form in bronchial passages. Fortunately, these types of ailments are all treatable to some degree, though they cannot be cured. For that reason, scientists continue to look for ways to improve current therapies.Currently, lung ailments such as cystic fibrosis, COPD and asthma are treated with inhaled drugs such as corticosteroids that adhere to the walls of air passages. In some instances, they are carried by what are known as mucoadhesive particles, (MAPs), but, as the researchers note, thick mucus often builds up on such passageways, lessening the effectiveness of the delivery system. In this new effort, the researchers took a different approach—rather than trying to make medicines that adhere do their job better, they turned to nanoparticles that are small enough to make their way through mucus membranes to the lining of the lungs themselves, offering direct medication application to affected areas. Called mucus-penetrating particles (MPP), they remain in the lungs, releasing medication for an extended period of time. The making of mucus in common lung diseases PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.org Explore further (Phys.org)—A team of researchers from multiple institutions in the U.S. has developed a new way to treat lung disease—using nanoparticles to transport chemicals through the thick mucus membranes that can coat pulmonary airways. In their paper published in the journal Science Advances, the team describes how they used particles small enough to move through holes in the mesh that makes up mucus to deliver helpful drugs.