Bayer Leverkusen has sold goalkeeper Bernd Leno to Arsenal for around €19 million, completing Unai Emery’s second major signing as manager.The 26-year-old German international Leno has arrived on a contract that should keep him at the Emirates until 2023, making him the long-term replacement for current number one Petr Cech, reports Four-Four-Two. Emery was delighted after unveiling his latest acquisition, saying: “We are very pleased that Bernd Leno will be joining us,”“Bernd is a goalkeeper of high quality and experience. We are all excited that Bernd has chosen Arsenal and look forward to start working with him in pre-season.” Merson believes Arsenal should sign Sancho Manuel R. Medina – September 14, 2019 Borussia Dortmund winger Jadon Sancho might be the perfect player to play for the Gunners, according to former England international Paul Merson.Welcome to Arsenal, @Bernd_Leno – we’re delighted to have you here ?#HeyLeno pic.twitter.com/m4yT22I58V— Arsenal FC (@Arsenal) June 19, 2018Leno was a major part of the Leverkusen squad that achieved a 5th place finish in the Bundesliga last year and he has won 6 caps for his country to date – though unfortunately, he did not make Joachim Lowes final squad for the World Cup.After the purchase of Stephan Lichtsteiner last month, Emery has managed to further enhance his options defensively with the signing of Leno, as his new look Arsenal side begins to take shape.
The leased lands are not only close to the pipeline, but allow companies to tap into two new prospects, the Nanushuk and Torok formations. Alaska Bureau of Land Management associate state director Ted Murphy pointed out that it is important to note that the further west you travel in the NPR-A the less infrastructure there is to support development. All of the leases sold adjoin current leases. Balash, who served as served as chief of staff to Senator Dan Sullivan and Natural Resources Commissioner under Governor Sean Parnell, had previously fought for an Alaska-led plan to allow modern seismic studies in ANWR. T ConocoPhillips and Anadarko, jointly bid on a total of about 80,000 acres, building upon the new Willow oil discovery made within NPR-A, and announced a year ago. During Balash’s tenure, the state filed a claim requesting the transfer of 20,000 acres in ANWR from the federal government to the state of Alaska. The BLM rejected the claim, and now Balash could have the power to overturn such a decision. Facebook0TwitterEmailPrintFriendly分享The U.S. Senate confirmed Alaskan Joe Balash to a top position at the Interior Department on Thursday, serving as assistant secretary for land and minerals management under Interior Secretary Ryan Zinke. While only seven of the 900 leases offered in the NPR-A were sold, causing strong discussion on the value of opening less accessible ANWR, it’s important to recognize that the short window between the announcement that the properties would be available and the actual lease offered minimal opportunity for planning and resource allocation for the bidders. During Balash’s Senate confirmation hearing, he pledged to work on speeding permits and allowing responsible drilling and mining, and improve recreational access to federal lands. Story as aired:http://www.radiokenai.us/wp-content/uploads/2017/12/Dorene-on-Alaskan-appointed-to-top-position-at-interior-department.mp3
“This was an attractive opportunity, and we intend to use the proceeds received at closing to pay down debt,” IP’s chairman and CEO John Faraci said in a statement. The down economy and reduced demand have taken a toll on paper makers. One producer, Sappi Fine Paper North America, announced that it will indefinitely suspend operations at its facility in Muskegon, Michigan, resulting in the furlough of approximately 190 salaried and hourly employees. The suspension is set to begin April 1.The company said the suspension was necessary in light of “significantly lower global demand for coated fine paper products.” As part of a separate cost-cutting initiative, Sappi also said it is eliminating an additional 70 positions company-wide.UPM is suspending production at a pair of its mills in Finland in April. The suspension is said to result in a 880,000-ton per-year reduction of coated and uncoated specialty paper as well as uncoated mechanical magazine paper.Meanwhile, Memphis, Tennessee-based International Paper said it is divesting the equivalent of 143,000 acres of properties located in southwestern U.S. The company is selling 114,000 acres to the American Timberlands Fund for $220 million in cash and donated the remaining acres (worth approximately $55 million) in exchange for a 20 percent investment in the fund.
MIDDLETON, MA — 87 members of the Essex County Sheriff’s Department (ECSD) have completed an interactive firearms training organized in conjunction with the Middlesex Sheriff’s Office (MSO), Sheriffs Kevin F. Coppinger and Peter J. Koutoujian announced this week.The training was held on the MSO’s Mobile Training Center (MTC), a specialized trailer that allows officers to practice their responses to critical incidents. MSO officers who operate the MTC can offer unique scenarios for each user to test their firearm, communication and de-escalation skills.“We are proud to share this resource with our law enforcement colleagues at ECSD. Our agencies regularly participate in trainings together, from our Crisis Intervention Training program to continuing education opportunities for staff, but this represents a new avenue for partnership,” said Sheriff Koutoujian. “This training allows officers to work through real life scenarios and practice their responses to a serious incident, all while receiving constructive feedback from ECSD instructors and MSO officers.”The MTC was stationed at the Middleton House of Correction from April 22 – May 3. ECSD staff practiced scenarios specifically tailored for the environments that deputies operate in, such as construction details which may involve a traffic encounter and inmate transportation.“Providing the most advanced training to our correctional officers is a priority of our department. We continually strive to provide high quality, situational training to our officers. Sharing this interactive training platform is an example of how Sheriffs’ Departments in the Commonwealth collaborate for the benefit of public safety,” said Sheriff Kevin Coppinger.In 2018, 19 police departments were trained through the MTC. So far this year, nine agencies – including the Essex County Sheriff’s Department – have utilized the MTC for at least one week of training.Photo L to R: ECSD Special Sheriff William Gerke, MSO Firearms Instructors Officers Frank Reid, Chris Hardy, Ret. Sgt. Don Cook, ECSD Sheriff Kevin F. Coppinger with ECSD Firearms Instructors Sgt. Jim Comeau, Security Investigator Jason Frampton, Security Investigator John Zaccari, Capt. Shelley Ehlers, Capt. Tom Cote, Assistant Superintendent/Director of Training Christine Arsenault.(NOTE: The above press release is from the Middlesex Sheriff’s Office.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedMiddlesex Sheriff’s Office Receives State Grant For Popular Youth Summer CampIn “Police Log”Attorney General Awards Middlesex Sheriff’s Office A Healthy Summer Youth Jobs GrantIn “Police Log”51 Wilmington Students Graduate From Middlesex Sheriff’s Youth Public Safety AcademyIn “Government”
There’s a new gray area in health research. For decades, scholars have looked at disparities through the lens of black and white. Changing demographics and growing immigrant populations are demanding new approaches that explore diversity within racial groups.“The Black population is not monolithic,” says Helena Dagadu, a fellow at the Robert Wood Johnson Foundation (RWJF) Center for Health Policy at Meharry Medical College who is preparing to complete her PhD in the Department of Sociology at Vanderbilt University. Dagadu is among the Center’s first cohort of doctoral fellows set to graduate in May 2015.A native of Ghana who came to the United States as a child, Dagadu is particularly interested in how health inequities affect black immigrant populations. “African immigrants represent one of the fastest-growing immigrant populations in the U.S.,” she says. Her research examines health disparities between the native-born American Black population and Black African immigrants—specifically as they relate to chronic, non-communicable conditions such as stroke, heart disease and diabetes.“The tide is turning in health research,” she says. “It’s moving toward an understanding that there are differences in black populations.”Dagadu’s observations align with a recent upsurge of interest in how underrepresented populations self-identify. According to the Pew Research Center, the 2010 census revealed that many communities, including Hispanics, Arabs, and people of mixed race, have said they’re unsure of which box to check on census forms.“The 2020 census will ask the race/ethnicity question differently,” says Dagadu. “They’re recognizing diversity within groups, which has implications for survey data coming out of the census. And we researchers get a lot of our data from those survey responses.”Like Dagadu, Courtney Thomas, PhD, another Meharry scholar, investigates the ways in which race and ethnicity influence health within black population groups.“The center of my research has been understanding health paradoxes,” says Thomas, who successfully defended her dissertation in sociology earlier this year. She will be joining the University of Kentucky faculty as an Assistant Professor of Sociology and African American and Africana Studies.“For example, we see that college-educated black women are at higher risk than lower-educated white women when it comes to maternal outcomes. I want to see how race and ethnicity figure into those outcomes.”Another area of interest for Thomas is the effects of race-based stressors and racial identity on mental wellbeing. “Even subtle forms of racial discrimination have a significant impact on mental health,” she explains. “The idea of not belonging—being unsure about how you’re viewed by others—causes stress and anxiety.”The negative effects are markedly greater for women than for men, Thomas adds. Subtler forms of racial discrimination have a greater impact on women, while more overt acts have a greater effect on men.Exploring how differences in social class and gender affect physical health and mental wellbeing is crucial, Thomas says. “It gives us a more nuanced understanding of black Americans’ health issues.”Both Thomas and Dagadu applaud the fellowship at Meharry for providing scholars with invaluable hands-on mentorship and leadership development. Another 11 fellows are currently pursuing doctoral studies.The Center, launched in 2009, has worked to increase the diversity of health policy leaders in the social, behavioral, and health sciences—particularly sociology, economics, and political science—who will one day influence health policy at the national level.“The RWJF fellowship has been a great complement to my PhD training,” says Dagadu. “We’ve had opportunities to hear the perspectives of prominent scholars interested in building a healthier America. I’ve gained practical professional development skills, and learned how to talk about my work to the media as well as influential policymakers working to eliminate health disparities.”She credits the experience with helping her land a position as an Endowed Assistant Professor of Sociology at Loyola University–Chicago. “I believe this program helped make my interview a success,” she says.“You can go to any research program and learn,” explains Thomas. “This fellowship has given me regular exposure to top scholars. Right from the beginning, I felt like I was in the middle of the field and I had a place at the table.”
“UVA played mistake-free doubles to open up the match,” said UofL head coach Rex Ecarma. “They won four deuce points early and we were fighting from behind. After they won No. 1 singles, the rest of the matches could have gone either way. David won and Sergio was winning. Fabien was up in the second set early. It’s obvious we have a special group of freshmen. UVA added two players in their top four. They are very improved team from last year.” #17 Virginia 4, Louisville 11/20/2019 at Charlottesville, Va.(Boar’s Head Sports Club)Singles1. Carl Soderlund (VA) def. #104 Brandon Lancaster (LOU) 6-1, 6-02. Brandon Nakashima (VA) vs. Christopher Morin-Kougoucheff (LOU) 6-3, 6-5, unfinished3. #38 Gianni Ross (VA) def. Fabien Salle (LOU) 6-2, 7-54. Henrik Wiersholm (VA) def. Federico Gomez (LOU) 6-3, 6-45. Aswin Lizen (VA) vs. Sergio Hernandez Ramirez (LOU) 3-6, 5-5, unfinished6. David Mizrahi (LOU) def. Matthew Lord (VA) 1-6, 6-2, 6-3Doubles1. Carl Soderlund/Matthew Lord (VA) vs. Christopher Morin-Kougoucheff/Fabien Salle (LOU) 5-3, unfinished2. Aswin Lizen/Gianni Ross (VA) def. Brandon Lancaster/Alex Wesbrooks (LOU) 6-33. Brandon Nakashima/Henrik Wiersholm (VA) def. Federico Gomez/Sergio Hernandez Ramirez (LOU) 6-1 The match was decided on court three where No. 38 Gianni Ross defeated freshman Fabien Salle 6-2, 7-5 for the 4-1 final. Virginia (2-0, 1-0 ACC) started the match by taking the doubles points with wins on courts 2 and 3. The Cavalier duo of Brandon Nakashima and Henrik Wiersholm defeated Lousville’s Federico Gomez and Sergio Hernandez Ramirez 6-1 at No. 3 and clinched the point at the two-spot where Aswin Lizen and Gianni Ross topped Brandon Lancaster and Alex Wesbrooks 6-3. Matchup History Preview The University of Louisville men’s tennis team fell 4-1 to No. 17 Virginia in its ACC opener Sunday in Charlottesville, Va. In singles action, Carl Soderlund defeated No. 104 Lancaster at the No. 1 seed to give Virginia a 2-0 lead. Wiersholm defeated Gomez 6-3, 6-4 at the four-spot to make the score 3-0. David Mizrahi put the Cardinals on the scoreboard with a 1-6, 6-2, 6-3 win over Matthew Lord at No. 6. With the victory, the freshman improves his dual match record to a team-best 4-0. Up next, the Cardinals (3-1, 0-1 ACC) will travel to Gainesville, Fla., to face Florida Atlantic in the first round of the ITA Kick-Off Weekend. Next Match: vs. Florida Atlantic 1/26/2019 | 11:00 a.m. Match Notes:Louisville 3-1, 0-1 ACCVirginia 2-0, 1-0 ACC; National ranking #17Order of finish: Doubles (3,2); Singles (1,4,6,3)T-2:00 A-257 Print Friendly Version Full Schedule Roster
Play Movie of nanoparticles moving through mucus. Credit: Schneider et al. Sci. Adv. 2017;3:e1601556 The nanoparticles, the team notes, were created using biodegradable materials that prior research found safe for internal use. Testing in mice, they report, showed the particle carriers stayed in the lungs for several hours—they also proved to be more effective than conventional therapies at reducing asthma symptoms such as irritation. The researchers suggest that MPPs could offer a better treatment plan for lung patients by providing a therapy that maintains drug levels in the lungs for longer periods of time, reducing the need for repeated dosing, which itself can cause lung irritation. PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen More information: Craig S. Schneider et al. Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation, Science Advances (2017). DOI: 10.1126/sciadv.1601556AbstractMucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that avoid mucoadhesion and have diameters smaller than mucus mesh spacings rapidly penetrate mucus layers [mucus-penetrating particles (MPP)], which we hypothesized would provide prolonged lung retention compared to MAP. We compared in vivo behaviors of variously sized, polystyrene-based MAP and MPP in the lungs following inhalation. MAP, regardless of particle size, were aggregated and poorly distributed throughout the airways, leading to rapid clearance from the lungs. Conversely, MPP as large as 300 nm exhibited uniform distribution and markedly enhanced retention compared to size-matched MAP. On the basis of these findings, we formulated biodegradable MPP (b-MPP) with an average diameter of <300 nm and examined their behavior following inhalation relative to similarly sized biodegradable MAP (b-MAP). Although b-MPP diffused rapidly through human airway mucus ex vivo, b-MAP did not. Rapid b-MPP movements in mucus ex vivo correlated to a more uniform distribution within the airways and enhanced lung retention time as compared to b-MAP. Furthermore, inhalation of b-MPP loaded with dexamethasone sodium phosphate (DP) significantly reduced inflammation in a mouse model of acute lung inflammation compared to both carrier-free DP and DP-loaded MAP. These studies provide a careful head-to-head comparison of MAP versus MPP following inhalation and challenge a long-standing dogma that favored the use of MAP for pulmonary drug delivery. Play Movie of nanoparticles moving through mucus. Credit: Schneider et al. Sci. Adv. 2017;3:e1601556 Citation: Nanoparticles pass through mucus membranes in lungs to deliver pulmonary drugs (2017, April 6) retrieved 18 August 2019 from https://phys.org/news/2017-04-nanoparticles-mucus-membranes-lungs-pulmonary.html Journal information: Science Advances Lung problems impact the lives of millions of people. Such conditions include asthma, in which bronchi spasm, making it difficult to breathe; cystic fibrosis, in which over-production of mucus leads to blocking of bronchi; and COPD, in which obstructions form in bronchial passages. Fortunately, these types of ailments are all treatable to some degree, though they cannot be cured. For that reason, scientists continue to look for ways to improve current therapies.Currently, lung ailments such as cystic fibrosis, COPD and asthma are treated with inhaled drugs such as corticosteroids that adhere to the walls of air passages. In some instances, they are carried by what are known as mucoadhesive particles, (MAPs), but, as the researchers note, thick mucus often builds up on such passageways, lessening the effectiveness of the delivery system. In this new effort, the researchers took a different approach—rather than trying to make medicines that adhere do their job better, they turned to nanoparticles that are small enough to make their way through mucus membranes to the lining of the lungs themselves, offering direct medication application to affected areas. Called mucus-penetrating particles (MPP), they remain in the lungs, releasing medication for an extended period of time. The making of mucus in common lung diseases PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.org Explore further (Phys.org)—A team of researchers from multiple institutions in the U.S. has developed a new way to treat lung disease—using nanoparticles to transport chemicals through the thick mucus membranes that can coat pulmonary airways. In their paper published in the journal Science Advances, the team describes how they used particles small enough to move through holes in the mesh that makes up mucus to deliver helpful drugs.